THE ROLE OF CCN4/WISP-1 IN THE CANCEROUS PHENOTYPE

The role of CCN4/WISP-1 in the cancerous phenotype

Mary P Nivison, Kathryn E Meier Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA Abstract: CCN proteins are secreted into the extracellular environment where they interact with both components of the extracellular matrix and with cell surface receptors to regulate

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Metal-independent variants of phosphoglycerate mutase promote resistance to nutritional immunity and retention of glycolysis during infection.

The ability of Staphylococcus aureus and other pathogens to consume glucose is critical during infection.However, glucose consumption increases the cellular demand for manganese sensitizing S.aureus to host-imposed manganese starvation.The current investigations were undertaken to elucidate how S.aureus copes with the need to consume glucose when m

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